Updated on November 19, 2020
Technical Scientist Mitsutaka Kadota, Ph.D. Email: mitsutaka.kadota (at) riken.jp |
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Career
| Period | Degrees and Appointments |
| 1992 - 1996 | School of Life Sciences, Faculty of Medicine, Tottori University, Japan (B.Sc. in March 1996) |
| 1996 - 1998 | Master degree program, Department of Molecular and Cell Genetics, School of Life Sciences, Faculty of Medicine, Tottori University, Japan (M.Sc.. in March 1998) |
| 1998 - 2003 | Doctoral course, Division of Molecular and Cell Genetics, Department of Molecular and Cellular Biology, School of Life Sciences, Faculty of Medicine, Tottori University, Japan (Ph.D. in March 2003; supervisor, Prof. Mitsuo Oshimura) |
| 1997 - 1998 | Research Assistant, Mishima Institute for Dermatological Research, Kobe, Japan |
| 2003 | Research Assistant, Department of Human Genome Science (Kirin Brewery Company, Ltd.), Graduate School of Medical Science, Tottori University, Japan |
| 2003 - 2008 | Visiting Fellow, Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA |
| 2008 - 2011 | Research Fellow, Laboratory of Population Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, USA |
| 2012 - 2016 | Research Scientist, Genome Resource and Analysis Unit, Center for Developmental Biology (CDB), RIKEN, Kobe, Japan |
| 2016 - 2018 | Senior Technical Scientist, Phyloinformatics Unit, Center for Life Science Technologies (CLST), RIKEN, Kobe, Japan |
| 2018 - | Technical Scientist, Laboratory for Phyloinformatics, Center for Biosystems Dynamics Research (BDR), RIKEN, Kobe, Japan |
Publications
Original papers
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Aburatani, N., Takagi, W., Wong, M.K., Kadota, M., Kuraku, S., Tokunaga, K., Kofuji, K., Saito, K., Good, W., Sakamoto, T., Hyodo, S. Facilitated NaCl uptake in the highly developed bundle of the nephron in Japanese red stingray Hemitrygon akajei revealed by comparative anatomy and molecular mapping. Zoolog. Sci. 2020, 37(5), 458-466. |
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Kusakabe, R., Higuchi, S., Tanaka, M., Kadota, M., Nishimura, O., Kuratani, S. Novel developmental bases for the evolution of hypobranchial muscles in vertebrates. BMC Biol. 2020, 18(1):120. |
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Kadota, M., Yamaguchi, K., Hara, Y., Kuraku, S. Early vertebrate origin of CTCFL, a CTCF paralog, revealed by proximity-guided shark genome scaffolding. Sci. Rep. 2020, 10(1):14629. |
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Okina, Y., Sato-Matsubara, M., Matsubara, T., Daikoku, A., Longato, L., Rombouts, K., Thanh, Thuy, L.T., Ichikawa, H., Minamiyama, Y., Kadota, M., Fujii, H., Enomoto, M., Ikeda, K., Yoshizato, K., Pinzani, M., Kawada, N. TGF-β-driven reduction of cytoglobin leads to oxidative DNA damage in stellate cells during non-alcoholic steatohepatitis. J. Hepatol. 2020, S0168-8278(20)30228-2 |
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Kadota, M., Nishimura, O., Miura, H., Tanaka, K., Hiratani, I., Kuraku, S. Multifaceted Hi-C benchmarking: what makes a difference in chromosome-scale genome scaffolding? Gigascience. 2020, 9(1). pii: giz158. |
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Mito, M., Kadota, M., Nakagawa, S., Iwasaki, S. TChIP-seq: Cell-type specific epigenome profiling. J. Vis. Exp. 2019, 143 |
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Hara, Y., Yamaguchi, K., Onimaru, K., Kadota, M., Koyanagi, M., Keeley, S.D., Tatsumi, K., Tanaka, K.,
Motone, F., Kageyama, Y., Nozu, R., Adachi, N., Nishimura, O., Nakagawa, R.,
Tanegashima, C., Kiyatake, I., Matsumoto, R., Murakumo, K., Nishida, K.,
Terakita, A., Kuratani, S., Sato, K., Hyodo, S., Kuraku, S. Shark genomes provide insights into elasmobranch evolution and the origin of vertebrates. Nat Ecol Evol. 2018, 2(11), pp 1761-1771 |
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Tanegashima, C., Nishimura, O., Motone, F., Tatsumi, K.,
Kadota, M., Kuraku, S. Embryonic transcriptome sequencing of the ocellate spot skate Okamejei kenojei. Sci. Data 2018, 5, 180200 |
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Nabeshima, R., Nishimura, O., Maeda, T., Shimizu, N., Ide, T., Yashiro, K.,
Sakai, Y., Meno, C., Kadota, M.,
Shiratori, H., Kuraku, S., Hamada, H. Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters. Elife 2018, 7, e36435 |
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Mito, M., Kadota, M., Tanaka, K.,
Furuta, Y., Abe, K., Iwasaki, S., Nakagawa, S. Cell type-specific survey of epigenetic modifications by tandem chromatin immunoprecipitation sequencing. Sci. Rep. 2018, 8(1), 1143 |
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Kadota, M.,
Hara, Y., Tanaka, K., Takagi, W., Tanegashima, C., Nishimura, O., Kuraku, S. CTCF binding landscape in jawless fish with reference to Hox cluster evolution. Sci. Rep. 2017, 7(1), 4957 |
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Okashita, N., Suwa, Y., Nishimura, O., Sakashita, N.,
Kadota, M., Nagamatsu, G., Kashida,
H., Nakajima, A., Tachibana, M., Seki, Y. PRDM14 drives oct3/4 recruitment via active demethylation in the transition from primed to naïve pluripotency. Stem Cell Reports 2016, 7(6), pp 1072-1086 |
| Hu, N., Kadota, M.,
Liu, H., Abnet, C.C., Su, H., Wu, H., Freedman, N.D., Yang, H.H., Wang,
C., Yan, C., Wang, L., Gere, S., Hutchinson, A., Song, G., Wang, Y,
Ding, T., Qiao, Y.L., Koshiol, J., Dawsey, S.M., Giffen, C., Goldstein,
A.M., Taylor, P.R., Lee, M.P. Genomic landscape of somatic alterations in esophageal squamous cell carcinoma and gastric cancer. Cancer Res. 76(7): 1714-1723, 2016 |
| Bae, E., Sato, M., Kim, R.J., Kwak, M.K., Naka, K., Gim, J., Kadota, M., Tang, B., Flanders, K.C., Kim, T.A., Leem, S.H., Park, T., Lie, F., Wakefield, L.M., Kim, S.J., Ooshima, A. Definition of smad3 phosphorylation events that affect malignant and metastatic behaviors in breast cancer cells. Cancer Res. 74(21): 6139-6149, 2014 |
| Sato, M., Kadota, M.,
Tang, B., Yang, H.H., Yang, Y.A., Shan, M., Weng, J., Welsh, M.A.,
Flanders, K.C., Nagano, Y., Michalowski, A.M., Clifford, R.J., Lee,
M.P., Wakefield, L.M. An integrated genomic approach identifies persistent tumor suppressive effects of transforming growth factor-beta in human breast cancer. Breast Cancer Res. 16(3): R57, 2014 |
| Adachi, K., Nikaido, I., Ohta, H., Ohtsuka, S., Ura, H.,
Kadota, M., Wakayama, T., Ueda, H.R., Niwa, H. Context-dependent wiring of Sox2 regulatory networks for self-renewal of embryonic and trophoblast stem cells. Mol. Cell 52(3): 380-392, 2010 |
| Kadota, M., Yang,
H.H., Gomez, B., Sato, M., Clifford, R.J., Meerzaman, D.,
Dunn, B.K., Wakefield, L.M., Lee, M.P. Delineating genetic alterations for tumor progression in the MCF10A series of breast cancer cell lines. PLoS One 5(2): e9201, 2010 |
| Kadota, M., Sato,
M., Duncan, B., Ooshima, A., Yang, H.H., Diaz-Meyer, N., Gere, S.,
Kageyama, SI., Fukuoka, J., Nagata, T., Tsukada, K., Dunn, B.K.,
Wakefield, L.M., Lee, M.P. Identification of novel gene amplification in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA. Cancer Res. 69: 7357-7365, 2009 |
| Kadota, M., Yang,
H.H., Hu, N., Wang, C., Hu, Y., Taylor, P.R., Buetow, K.H., Lee, M.P.
Allele-specific chromatin immunoprecipitation studies show genetic influence on chromatin state in human genome. PLoS Genet. 3, 0768-0778, 2007 |
| Kadota, M.,
Nishigaki, R., Wang, C.C., Toda, T., Shirayoshi, Y., Inoue, T.,
Gojobori, T., Ikeo, K., Rogers, M.S., Oshimura, M. Proteomic signatures and aberrations of mouse embryonic stem cells containing a single human chromosome in neuronal differentiation: an in vitro model of Down syndrome. Neuroscience 129: 325-335, 2004 |
| Torisu,
H., Yamamoto, T., Fujiwaki, T., Kadota,
M., Oshimura, M., Kurosawa, K., Akaboshi, S., Oka, A. Girl with monosomy 1p36 and Angelman syndrome due to unbalanced der(1) transmission of maternal translocation t(1; 15)(p36.3;q13.1). Am. J. Med. Genet. 131A (1): 94-98, 2004 |
| Wang,
C.C., Kadota, M.
(equal first author), Nishigaki, R., Kazuki, Y., Shirayoshi, Y.,
Rogers, M.S., Gojobori, T., Ikeo, K., Oshimura, M. Molecular hierarchy in neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochem. Biophys. Res. Comm. 314: 335-350, 2004 |
| Fujii,
S., Luo, R.Z., Yuan, J., Kadota,
M., Oshimura, M., Dent, S.R., Kondo, Y., Issa, J.P., Bast,
R.C. Jr., Yu, Y. Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation. Hum. Mol. Genet. 12: 1791-1800, 2003 |
| Yuan,
J., Luo, R.Z., Fujii, S., Wang, L., Hu, W., Andreeff, M., Pan, Y., Kadota, M.,
Oshimura, M., Sahin, A.A., Issa, J.P., Bast, R.C. Jr., Yu, Y. Aberrant methylation and silencing of ARHI, an imprinted tumor suppressor gene in which the function is lost in breast cancers. Cancer Res. 63: 4174-4180, 2003 |
| Kadota, M.,
Shirayoshi, Y., Oshimura, M. Elevated apoptosis in pre-mature neurons differentiated from mouse ES cells containing a single human chromosome 21. Biochem. Biophys. Res. Comm. 299: 599-605, 2002 |
| Inoue,
J., Mitsuya, K., Maegawa, S., Kugoh, H., Kadota, M.,
Shinohara, T., Nishihara, S., Takehara, S., Yamauchi, K., Schulz, T.C.,
Oshimura, M. Construction of 700 human/mouse A9 monochromosomal hybrids and analysis of imprinted genes on human chromosome 6. J. Hum. Genet. 46: 137-145, 2001 |
Review papers
| Murakami, K., Nishigaki, R., Kazuki, Y., Kadota, M., Oshimura, M. Proteomics and epigenetics learned from Down syndrome model mouse. Seikagaku 76: 1296-1304, 2004 |
| Yu, Y., Fujii, S., Yuan, J., Luo, R.Z., Wang, L., Bao, J., Kadota, M.,
Oshimura, M., Dent, S.R., Issa, J.P., Bast, R.C. Jr. Epigenetic regulation of ARHI in breast and ovarian cancer cells. Ann. N.Y. Acad. Sci. 983: 268-277, 2003 |
| Yoshino, K., Kamijo, M., Kimura, M., Mishima, Y., Kondoh, H., Kadota, M.,
Ito, S., Wakamatsu, K., Kakihana, H. A further mechanism study of boron accumulation to and release from melanoma with para-Boronophenylalanine. Frontiers in Neutron Capture Therapy, vol 2, 985-990, 2001 |
Other papers and technical documents
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田中かおり,
門田満隆 ChIP-seq実験を成功に導くための秘訣：ChIP条件の最適化とサンプルQCについて 実験医学, 2016, 第34巻16号, pp 2705-2710 |
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門田満隆,
蓑田亜希子 ヒストン修飾や転写因子の結合領域を同定するコツやポイント 実験医学別冊 次世代シークエンス解析スタンダード2014, pp 105-121 |
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村上芳里,
西垣竜一,
香月康宏,
門田満隆,
押村光雄 ダウン症候群モデルマウスから学んだプロテオミクスとエピジェネティクス 生化学, 2004, 第76巻10号, pp 1296-1304 |
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三嶋豊,
波多江慎吉,
近藤浩文,
門田満隆 第3世代色白剤の研究・開発 フレグランスジャーナル, 1998, 第26巻1号, pp 34-44 |
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門田満隆 結節性硬化症原因遺伝子（TSC2）の機能解析：ヒト16番染色体移入によるEkerラット腎がん由来細胞株（ERC15）の増殖抑制 米子医学雑誌, 1996, 第47巻5/6号 pp 296-304 |